Changes in the bacteial spectrum and antibiotic resistance pattern of uropatho­gens at our department between 2004 and 2017

DOI: 10.22591/magyurol.2018.3.magyara.96

Authors:
Magyar András dr.¹, Dobák András dr.², Bálint Péter dr.¹, Vinodh Kumar Adithyaa Arthanareeswaran dr.³, Nagy Károly dr.¹, Póth Sándor dr.¹, Bata Anikó dr.¹, Tenke Péter dr.¹, Köves Béla dr.^1
1Jahn Ferenc Dél-pesti Kórház és Rendelőintézet, Urológiai osztály, Budapest (osztályvezető: Tenke Péter dr.)
²Corden International, Budapest
³Lipcsei Egyetem, Urológiai Klinika, Németország (igazgató: Jens-Uwe Stolzenburg dr.)

Summary

Objective: Since bacterial antibiotic resistance rates may vary with significant differences between countries and regions, as well as change over time, yearly surveillance of the bacterial spectrum and antibiotic-resistance patterns of locally occurring uropathogens is essential to serve as a basis for empirical treatment of urinary tract infections (UTIs). The objective of our study was to investigate the changes in the bacterial spectrum and the antibiotic resistance rates of uropathogens cultured from urine samples collected at our department.
Material and methods: All urine samples taken at our department, from 2004 to 2017 were retrospectively analyzed. The significance rates of the annual changes were calculated using Cochran-Armitage test (p<0.05).
Results: A total of 3513 urine cultures showed significant presence of pathogens. Escherichia coli and Enterococcus faecalis were the most frequently isolated bacteria. Resistance of E. coli to ciprofloxacin has increased significantly, reaching a rate of 25%, while in the case of cephalosporines, resistance of E. coli remained under 20%.
Conclusion: For empirical treatment fluoroquinolones can be no longer recommended in our region. Gram-negative UTIs can be safely treated with cephalosporines, however, they should be avoided if multi-drug resistant bacteria are suspected. Surveillance and monitoring of the bacterial resistance patterns is recommended for all institutions.

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