Not every periurethral lesion is benign: lessons from a vulvar melanoma
DOI: 10.22591/magyurol.2026.2.molnarlg.83
Authors:
Molnár Lili Gabriella dr.1, Bartek Virág dr.1, Berta Tibor Benjámin dr.2,
Badényi Gábor dr.3, Seres Botond dr.3, Beöthe Tamás dr.2
1Nógrád Vármegyei Szent Lázár Kórház, Urológiai Osztály, Salgótarján
2Dél-Pesti Centrumkórház, Budapesti Péterfy Sándor Utcai Kórház-Rendelőintézet, Urológiai Osztály, Budapest
3Dél-Pesti Centrumkórház, Budapesti Péterfy Sándor Utcai Kórház-Rendelőintézet, Szülészet-Nőgyógyászati Osztály, Budapest
Summary
Introduction: Primary malignant melanoma of the vulva is the second most common malignant tumor of the female external genitalia. The disease is often detected at an advanced stage and is associated with high mortality. Treatment is determined by the extent of the tumor; in some advanced cases, only palliative management is possible (stoma formation, urinary diversion), while in other cases, surgery may be the first-
line treatment followed by adjuvant therapy. In our case, we present the management of a periurethral vulvar melanoma that posed a differential diagnostic challenge.
Case report: A 65-year-old female patient presented to our outpatient clinic with vaginal bleeding and a firm mass completely covering the urethra. Physical examination confirmed a friable lesion that had enlarged compared to the size previously documented at another institution. Imaging studies raised the possibility of a malignant process. Histopathological sampling from the periurethral region confirmed a lentiginous type periurethral vulvar melanoma. Following multidisciplinary tumor board evaluation, adjuvant immunotherapy was initiated, and close follow-up was planned.