The role of Uro-Vaxom in the treatment and prevention of acute cystitis
DOI: 10.22591/magyurol.2019.2.magyara.78
Authors:
Magyar András dr., Tenke Péter dr.
Jahn Ferenc Dél-pesti Kórház és Rendelőintézet, Urológiai Osztály, Budapest (osztályvezető: Tenke Péter dr.)
Summary
Introduction: Non-antibiotic approaches are of high priority in the prevention of recurrent cystitis, due to the global emergence of bacterial resistance to antibiotics. Uro-vaxom (OM-89), a lyophilized extract of Escherichia coli, is one of the most important drugs for non-antibiotic prophylaxis of recurrent cystitis. Its efficacy for reducing recurrent cystitis episodes has been investigated in several studies. Our objective was to review available publications on this immunoprophylactic drug.
Methods: A PubMed search was performed and references from available systematic reviews were summarised. The main outcomes of interest were: 1) the effects of the drug, 2) its efficacy in the prevention of recurrent cystitis episodes, 3) development of immunity versus several pathogens, 4) time of the initiation of the treatment 5) drug administration schemes and scheduling. Results: prophylaxis with Uro-Vaxom decreases the episodes of recurrent cystitis by 36% for at least 6 months therefore the administration of antibiotics may be reduced. Its efficiency is not influenced by the causative pathogen.
Conclusions: Out of all agents for non-antibiotic prophylaxis of acute cystitis Uro-Vaxom has the strongest evidence of its efficiency, which may be further amplified by its intermittent use.