Test methods and indications for DNA fragmentation analysis of spermatozoa
DOI: 10.22591/magyurol.2021.3.mateg.125
Authors:
Máté Gábor dr.1,2, Balló András dr.1,2, Török Attila dr.1
1Pannon Reprodukciós Intézet, Tapolca (igazgató: Török Attila dr.)
2Pécsi Tudományegyetem, Urológiai Klinika, Pécs (igazgató: Szántó Árpád dr.)
Summary
Male infertility is a problem that affects about half of couples in infertility treatment. In reality, this number may be much higher, as recent research confirms that infertility of idiopathic origin (15-30% of cases), when no problems are found in conventional andrological examinations, increased sperm DNA fragmentation value can be detected. However, it is not the only case when an increased DNA fragmentation can be observed. Several studies have found an increase in the DNA fragmentation index in couples with habituated abortions, multiple failed assisted reproduction cycles, leukocytospermia, varicocele, high sperm reactive oxygen radicals, and so on. In our manuscript we would like to present the indications in the literature for sperm DNA fragmentation testing and DNA fragmentation testing methods.