Results of penile rehabilitation with avanafil after laparoscopic radical prostatectomy

DOI: 10.22591/magyurol.2017.2.kerenyig.64

Authors:
Kerényi Gábor dr., Szepesváry Zsolt dr., Mosonyi Péter dr., Törzsök Ferenc dr. (Petz Aladár Megyei Oktató Kórház, Urológiai Osztály, Győr (osztályvezető: Szepesváry Zsolt dr.))

Summary

Objective: Investigation of erectile function of penis by administration of avanafil in patients operated with laparoscopic nervesparing radical prostatectomy, its impact on quality of life, furthermore compare the same parameters of data with a group of patients not received medication.
Patients and methods: Authors investigated patients operated with laparoscopic radical prostatectomy on Urology Department of Petz Aladár County Teaching Hospital between 2012 and 2016. Preoperative erectile function was appointed by score of „Questionnaire on quality of erection” (MMM) – a shortened form of IIEF used in Hungary. 26 patients met criteria (MMM score 17 at least) in group of penile rehabilitation (2015– 2016) and 25 men was included in control group (2012–2015). In „patients with medicine” group next catheter removal 100 mg avanafil was administered once daily for 60 days, and 200 mg casually after that. For measuring efficacy (satisfying erection for sexual intercourse) “MMM” questionnaire was also used in addition a specially compiled list of questions. Postoperatively quality of life score was determined by EQ-5D and VAS questionnaire 6-9 months after the operation.
Results: Differences in all of the endpoints of this survey (satisfying erection for vaginal insertion, successful sexual intercourse, increase in postoperative MMM score, improvement in Quality of Life parameters) was proven statistically significant in favour of avanafil medication group.
Authors remark that data processed during this study were neither prospective nor randomized, but was a comparison of parameters between metachronous groups.
Conclusion: There are several studies for penile rehabilitation with PDE-5 inhibitors attainable in international literature. Pharmaceutical agent in most studies is sildenafil, as well as tadalafil and vardenafil. On the score of present survey the newest phosphodiesterase type-5 inhibitor, avanafil seems to have its place among methods of early correction of circulation of penis after nervesparing radical prostatectomy.

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